Methadone During World War II Essay - 791 Words

Methadone General Information The IUPAC name of methadone is (RS)-6-(Dimethylamino)-4,4-diphenylheptan-3-one. Other common names for methadone include: Symoron, Dolophine, Amidone, Methadose, Physeptone, Heptadon, and others. The molecular formula for methadone is C21H27NO and its molecular weight is 309.44518 g/mol. Methadone exhibits two enantiomers, Levomethadone (R-(-)-Methadone) and dextromethadone (S-(+)-methadone). It has a specific optical rotation of -32 deg at 20 deg C/D. It also has a melting point of 235 degrees Fahrenheit. Methadone’s History and Uses During World War II, the United States and our allies cut off Germany’s opium supply. As a result, German scientists developed methadone in 1937 as an attempt to develop a synthetic opioid that could be created with readily available precursors in order to solve Germany’s opium shortage. These scientists were working for I.G. Farbenindustrie AG at the Farbwerke Hoechst. Upon completion of the war, Farbwerke Hoechst was required by the U.S. Department of Commerce to relinquish all patents, trade names, and research records. In 1947, the Council on Pharmacy and Chemistry of the American Medical Association gave the drug its generic name â€Å"methadone†. As the patent rights of â€Å"methadone† were no longer protected, any pharmaceutical company interested in the product could invest with ease. In 1947, Eli Lilly and Company became the first pharmaceutical company to introduce methadone into the UnitedShow MoreRelatedHeroin And Its Effects On The Hum an Body1534 Words   |  7 Pagescommonly considered one of the most dangerous, addictive, fatalist drugs in the world and treating this form of addiction, can be a complicated process for anyone wishing to kick off this habitual use. However, determining what treatment method best benefits a person, seeks no easy answer to a very complex problem. 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